Chemotherapy is a common practice for malignant mesothelioma, which is used to prevent cancer cells and prevent multiplication. Mesothelioma chemotherapy can be used in combination or surgery. Researchers have continued to study the effectiveness of new applications and chemotherapy drugs.
There are many chemotherapy drugs to treat mesothelioma cancer, although the standard first-line treatment is cisplatin or carboplatin with pemetrexed. The most recent studies have shown success in the combination of chemotherapy drugs and immunotherapy, and surgery with intensive chemotherapy called HIPEC has become a popular treatment for peritoneal mesothelioma.
Chemotherapy uses drugs to kill cancer cells and stop them from multiplying, stopping the metastasis or spread of cancer. There are two methods of controlling chemotherapy, which is regularly used as part of multimodal treatment in combination with surgery and radiotherapy. If used before surgery, the procedure is called neoadjuvant chemotherapy and, if used later, is called adjuvant chemotherapy.
Systemic chemotherapy is given intravenously (intravenously) or as a pill. Then travel through the bloodstream to reach the entire body. As a result, fast-growing cells such as hair follicle and healthy blood cell cells can also be reduced along with cancer cells and this type of chemotherapy can produce most of the treatment side effects.
Intraoperative chemotherapy is administered during surgery and applied directly to the area where mesothelioma tumours are formed. With the direct application, this type of chemotherapy does not affect the entire body. As a result, intraoperative chemotherapy generally has fewer side effects than systemic chemotherapy.
First and second line chemotherapy
Chemotherapy can be called the first line, second line or third line, depending on the order in which it is administered after a diagnosis of mesothelioma. The preferred top-level chemotherapy treatment for mesothelioma is a combination of cisplatin or platoplatin-based carboplatin and pemetrexed. If patients do not respond to first-line cancer treatment, doctors will probably recommend a second-line treatment option, which may vary from case to case.
Types of Mesothelioma Chemotherapy
Case studies continue to analyze the effectiveness of different types of chemotherapy drugs and applications of systemic chemotherapy, taking into account the type of mesothelioma, cell type, patient characteristics and staging.
Chemotherapy drugs for mesothelioma
Oncologists will determine which chemotherapy drug is best for the patient, taking into account several factors, including side effects. The chemotherapy drugs and the dose can be modified if the patient does not respond well to the treatment.
Alimta brand pemetrexed is one of the most common chemotherapy drugs used to treat mesothelioma and other cancers such as lung cancer. It is usually used in combination with a platinum-based drug such as cisplatin or carboplatin. The drug is injected for administration and patients often receive corticosteroids, vitamin B9 (folic acid) and vitamin B12 supplements to combat common side effects. This has been shown to prolong the patient’s life expectancy up to several months in many cases.
Information on intravenous administration. Studies have shown that this combination can be extended to the average patient duration at 12.1 months, compared to 9.3 months if used alone. In many cases, cisplatin is used in patients who can not be removed by surgery.
Carboplatin is another platinum-based drug, derived from cisplatin in the 1980s. Carboplatin generally has fewer side effects than cisplatin and is, therefore, a better option for some patients.
Gemcitabine, the Gemzar brand, is a less frequent chemotherapy drug that has been relatively effective in chemotherapy studies with mesothelioma. The drug has been used in combination with a platinum-based drug, but it has been used as a second-line treatment option for patients who do not respond to other medications.
Vinorelbine, a Navelbine brand, is a less common chemotherapy drug used primarily for the treatment of non-small cell lung cancer but is quite Effective in the treatment of mesothelioma. This medication is apoptosis, or programmed cell death, in cancer cells. Vinorelbine if it can be used as a first or second line for mesothelioma.